From a statement issued by Lufthansa:

Lufthansa commenced its new non-stop service between Frankfurt and Panama City today. Flight LH 484 departed from Frankfurt (FRA) at 10:15 local time, and is scheduled to arrive at the Aeropuerto Internacional de Tocumen in Panama City (PTY) at 16:40 local time this afternoon. Eastbound flight LH 485 will leave Panama City at 18:45 local time this evening, and is due to land in Frankfurt at 11:35 local time tomorrow (3 March). Lufthansa will be operating a five-times-weekly service on the new route all year round.

Panama, which is located between Costa Rica and Colombia, has experienced strong and accelerating economic growth in the last few years. In addition to the world-famous Panama Canal, the country’s substantial banking sector, its favorable geographic location and its well-developed infrastructure are all key reasons for business and leisure travellers to visit this Central American country. With its unspoilt beaches and its large number of national parks featuring rainforest, mangroves and a unique underwater world, Panama offers vacationers in particular an unforgettable stay.

Panama is also an ideal starting point for exploring various Central American countries and the islands of the Caribbean. And in this regard, Lufthansa’s new bilateral codeshare agreement with Copa Airlines, on of Central America’s leading air carrier, which is based in Panama City, offers a wide range of advantageous onward travel options.

Under the new codeshare accord, Lufthansa travellers can fly on with Star Alliance partner Copa Airlines from Panama City to any of 73 further destinations in Ecuador, Venezuela, Peru and Costa Rica, many of them bookable under Lufthansa flight numbers. In return, Copa Airlines customers gain access to the global network of the Lufthansa Group, which currently extends to 261 destinations in 101 countries.

More on this topic

More Flights Between Panama and Frankfurt

May 2018

Lufthansa has been announced that from November 3 it will add an additional frequency to its air route between Tocumen International Airport and the German city.

With this new frequency the Lufthansa airline will run six flights a week between Panama City and the city of Frankfurt.

New Costa Rica - Frankfurt Direct Flight

July 2017

Lufthansa has announced that from March 2018 it will start operating two flights per week between Juan Santamaría International Airport and the German city of Frankfurt.

Flights to San Jose will take place on an Airbus A340-300, which has 279 seats that cover Business, Premium Economy and Economy Class.  Flight LH518 departs from the Lufthansa Frankfurt hub at 13:45 and arrives in San José late in the afternoon at 5:55 pm local time. The return flight departs from San Jose in the afternoon at 7:50 p.m. and lands at Frankfurt Airport the following day at 3:10 p.m. with a flight time of approximately 11 hours.

Direct Flights Between Frankfurt and Panama

January 2016

Lufthansa has announced that the start of its direct route Panama City - Frankfurt is scheduled for March 2, with 5 flights a week.

The start of operations was originally scheduled for November 2015.

As reported on Laestrella.com.pa, the German airline said "...The frequency will be five times a week with an Airbus A340-300. "

New Flight Between Panama and Germany

February 2015

As of November 16 the German airline Lufthansa will operate five weekly flights between Tocumen International Airport and Frankfurt.

From a statement issued by Lufthansa Group:

From November 16, 2015, the airline will offer flights throughout the year to the city of Panama, subject to government approval.